By Jonathan Brocklehurst MSc MIRL MRCPod, Jana Albader BSc and Abigael Egan
DOI: 10.56885/738425cqsypi
Abstract: Diabetes-related foot ulceration (DFU) remains one of the most multifactorial complications of diabetes mellitus, responsible for high rates of lower limb amputation (LLA), excess mortality, and major health-system expenditure. Despite obesity and DFU growing exponentially worldwide and sharing many interconnected risk factors, peer-reviewed literature exploring the associations between these two conditions is limited. This review synthesizes epidemiological, genetic, and mechanistic data to argue that obesity should be positioned centrally in DFU risk assessment and management. Establishing responsive and personalized treatments and management plans for individuals with obesity and DFUs is important for effective limb preservation.